Most people with DLB do not have affected family members, although occasionally DLB runs in a family. A definitive diagnosis usually requires an autopsy. A presumptive diagnosis can be made if several disease features are present, such as symptoms or certain results of blood tests, neuropsychological tests, imaging, and sleep studies. Other core features are visual hallucinations, marked fluctuations in attention or alertness, and parkinsonism ( slowness of movement, trouble walking, or rigidity). RBD may appear years or decades before other symptoms. REM sleep behavior disorder (RBD)-in which people lose the muscle paralysis that normally occurs during REM sleep and act out their dreams-is a core feature.
The disease was first described by Kenji Kosaka in 1976. It is a common form of dementia, but the prevalence is not known accurately and many diagnoses are missed. Together with Parkinson's disease dementia, DLB is one of the two Lewy body dementias.
The disease worsens over time and is usually diagnosed when cognitive decline interferes with normal daily functioning. Memory loss is not always an early symptom. Microscopic image of a Lewy body (arrowhead) in a neuron of the substantia nigra scale bar=20 microns (0.02mm)ĭementia, abnormal behavior during REM sleep, fluctuations in alertness, visual hallucinations, parkinsonism Īlzheimer's, Parkinson's disease dementia, certain mental illnesses, vascular dementia Īcetylcholinesterase inhibitors such as donepezil and rivastigmine melatonin Īverage survival 8 years from diagnosis ĭementia with Lewy bodies ( DLB) is a type of dementia characterized by changes in sleep, behavior, cognition, movement, and regulation of automatic bodily functions. Medical condition Dementia with Lewy bodiesĭiffuse Lewy body disease, dementia due to Lewy body disease
0 kommentar(er)
